Acid and base degraded products of ketorolac

Salaris, Margherita and Nieddu, Maria and Rubattu, Nicola and Testa, Cecilia and Luongo, Elvira and Rimoli, Maria Grazia and Boatto, Gianpiero (2010) Acid and base degraded products of ketorolac. Journal of Pharmaceutical and Biomedical Analysis, Vol. 52 (2), p. 320-322. eISSN 1873-264X. Article.

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DOI: 10.1016/j.jpba.2010.01.031

Abstract

The stability of ketorolac tromethamine was investigated in acid (0.5 M HCl) and alkaline conditions (0.5 M NaOH), using the same procedure reported by Devarajan et al. [2]. The acid and base degradation products were identified by liquid chromatography-mass spectrometry (LC-MS).

Item Type:	Article
ID Code:	4442
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Ketorolac, acid and base stability, degradation products, LC–MS
Subjects:	Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:	Elsevier
eISSN:	1873-264X
Deposited On:	31 Aug 2010 18:41

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