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Enantiomeric separation by HPLC of 1,4-dihydropyridines with vancomycin as chiral selector

Boatto, Gianpiero and Nieddu, Maria and Faedda, Maria Virginia and De Caprariis, Paolo (2003) Enantiomeric separation by HPLC of 1,4-dihydropyridines with vancomycin as chiral selector. Chirality, Vol. 15 (6), p. 494-497. eISSN 1520-636X. Article.

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DOI: 10.1002/chir.10238

Abstract

The macrocyclic antibiotics represent a relatively new class of chiral selectors in CE, HPLC, and TLC. We have examined the use of the macrocyclic antibiotic vancomycin as a chiral selector in HPLC for the separation of 1,4-dihydropyridines (DHPs) calcium antagonists (CAs). Chromatographic data of six 1,4-dihydropyridine calcium channel blockers obtained on the vancomycin chiral stationary phase (Chirobiotic V) were compared with those obtained on an alpha(1)-acid glycoprotein (AGP) HPLC stationary phase. Optimization of pH and organic modifier was carried out in order to modulate the retention properties of each system. All chiral neutral DHPs were resolved on the AGP column, whereas on Chirobiotic V only basic DHPs showed a split peak. The analytical chromatographic procedure on Chirobiotic V proved suitable for semipreparative separation, since the separation factor on the analytical column was high enough to obtain pure enantiomers with high yields.

Item Type:Article
ID Code:4435
Status:Published
Refereed:Yes
Uncontrolled Keywords:Chirobiotic V, chiral AGP, chiral separation, amlodipine, felodipine, isradipine, lercanidipine, nimodipine, nisoldipine
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Wiley-Liss
eISSN:1520-636X
Deposited On:31 Aug 2010 18:43

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