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Determination of phenol and o-cresol by GC/MS in a fatal poisoning case

Boatto, Gianpiero and Nieddu, Maria and Carta, Antonio and Pau, Amedeo and Lorenzoni, Salvatore and Manconi, Paola Maria and Serra, Domenico (2004) Determination of phenol and o-cresol by GC/MS in a fatal poisoning case. Forensic Science International, Vol. 139 (2-3), p. 191-194. eISSN 1872-6283. Article.

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DOI: 10.1016/j.forsciint.2003.10.023


A fatality due to the ingestion of solution containing phenol and o-cresol is described. The pathological findings were typical of acute substantial poisoning. Blood, urine and stomach content were obtained during post mortem examinations. Phenol and o-cresol were identified using GC/MS. The extractions from autopsy materials were obtained as follows: by gel permeation with cyclohexane/dichloromethane from stomach content, by solid phase extraction (SPE) from urine and by deproteinization with acetonitrile from blood. The phenol and o-cresol concentrations in the samples were found, respectively, as follows: 115.0 and 5.0 μg/g in the stomach contents, 58.3 and 1.9 μg/ml in the blood, 3.3 and 20.5 μg/ml in the urine. Distributions of phenol in fatal poisonings have been reported [J. Forensic Sci. 27 (1982) 729; Forensic Sci. Int. 19 (1982) 177], but, usually, colorimetry was used as the analytical method and it cannot exclude the interference of other phenolic compounds.

Item Type:Article
ID Code:4431
Uncontrolled Keywords:Phenol, cresol, gel permeation, SPE, GC/MS
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari > Unità operativa di patologia forense
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Elsevier Science Ireland
Deposited On:31 Aug 2010 18:40

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