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Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection

Boatto, Gianpiero and Nieddu, Maria and Carta, Antonio and Pau, Amedeo and Palomba, Michele Francesco Luigi and Asproni, Battistina and Cerri, Riccardo (2005) Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection. Journal of Chromatography B, Vol. 814 (1), p. 93-98. eISSN 1873-376X. Article.

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DOI: 10.1016/j.jchromb.2004.10.010

Abstract

In recent years, the frequent appearance of phenethylamine designer drugs on the illicit drug market has been a matter of concern for all authorities involved. New phenethylamine drugs are being introduced because these compounds are not covered by existing legislation. Therefore, the new drugs cannot be considered illicit drugs until their names are officially recognized. This paper describes a method to screen for and quantify four 2,5-methylenedioxy-derivatives of 4-thio-phenethylamine (2C-T-series) in human plasma, using capillary electrophoresis coupled with electrospray ionisation-mass spectrometry (CE-ESI-MS). Prior to CE-MS analysis, a simple liquid extraction was used for sample cleanup. The method was validated according to international guidelines.

Item Type:Article
ID Code:4430
Status:Published
Refereed:Yes
Uncontrolled Keywords:Methylenedioxy-derivates, amphetamine, phenylethylamine, designer drug, urine, capillary electrophoresis, mass spectrometry, solid-phase extraction (spe)
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Elsevier B.V.
eISSN:1873-376X
Copyright Holders:© 2004 Elsevier B.V.
Deposited On:31 Aug 2010 18:40

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