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Two cases of chronic lymphoproliferative disorders in psoriatic patients treated with cyclosporine: hairy cell leukemia and Waldenstrom macroglobulinemia

Fozza, Claudio and Dore, Fausto and Bonfigli, Silvana and Podda, Luigi and Longinotti, Maurizio Roberto (2005) Two cases of chronic lymphoproliferative disorders in psoriatic patients treated with cyclosporine: hairy cell leukemia and Waldenstrom macroglobulinemia. European Journal of Dermatology, Vol. 15 (4), p. 271-273. eISSN 1952-4013. Article.

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Abstract

The real risk of lymphoproliferative disease in psoriatic patients has not yet been defined. Two explanations can be given for the occurrence of these malignancies: the broad immune activation typical of psoriasis and the administration of an immuno-suppressive treatment. A few studies describing the development of non Hodgkin lymphomas in psoriatic patients undergoing cyclosporine A have been published, but data about the occurrence of chronic lymphoproliferative disorders have never been reported. Here we describe the occurrence of hairy cell leukemia and Waldenstrom macroglobulinemia in two psoriatic patients treated with cyclosporine A. It remains unclear in our cases of chronic lymphoproliferative disease, as well as in the reported cases of psoriatic patients who develop lymphomas, whether psoriasis or the immunosuppressive treatment could play a role, although it is not possible to exclude a synergism between these factors.

Item Type:Article
ID Code:4429
Status:Published
Refereed:Yes
Uncontrolled Keywords:Cyclosporine, hairy cell leukemia, HCL, psoriasis, Waldenstrom macroglobulinemia
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 03 Istituti > Ematologia
Publisher:John Libbey Eurotext
eISSN:1952-4013
Deposited On:31 Aug 2010 17:39

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