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Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol

Vitale, Antonella and Guarini, Anna and Ariola, Cristina and Mancini, Marco and Mecucci, Cristina and Cuneo, Antonio and Pane, Fabrizio and Saglio, Giuseppe G. and Cimino, Giuseppe and Tafuri, Agostino and Meloni, Giovanna and Fabbiano, Francesco and Recchia, Annamaria Grazia and Kropp, Maria Grazia and krampera, Mauro and Cascavilla, Nicola and Ferrara, Felicetto and Romano, Antonio and Mazza, Patrizio and Fozza, Claudio and Paoloni, Francesca Paola and Vignetti, Marco and Foà, Robin (2006) Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol. Blood, Vol. 107 (2), p. 473-479. eISSN 1528-0020. Article.

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DOI: 10.1182/blood-2005-04-1754

Abstract

Between 1996 and 2000, 90 newly diagnosed adult patients with T-acute lymphoblastic leukemia (T-ALL) were registered in the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Leucemia Acuta Limfoide (LAL) 0496 protocol. Cases were centrally processed for morphology, immunophenotype, cytogenetics, molecular biology, and multidrug resistance (MDR). Twenty-two patients were females and 68 were males. Four percent of cases were pro-T, 47% pre-T, 39% cortical T, and 10% mature T-ALL. Fifty-six percent of patients with pro-T + pre–T-ALL achieved complete remission (CR) compared with 91% for cortical + mature cases (P = .002). CD34 expression was associated with a significantly lower CR rate: 54% versus 84% (P = .009). Thirty-one (36.5%) of 85 patients had an abnormal karyotype, the most common abnormality (15%) being a partial del(6q). The cytogenetic profile did not impact on CR achievement. MDR1 function, present in 26% of cases, correlated significantly with CR achievement (P = .004). A highly significant (P = .001) difference in CR rate was observed between patients who did not express the CD13/CD33/CD34 antigens and were MDR functionally negative (96%) compared with patients positive for at least one of these markers (57%). Multivariate analysis showed an impact on CR achievement for CD33 expression and MDR1 function. An extensive biologic workup of adult T-ALL cases at presentation is recommended in order to design tailored therapeutic strategies aimed at improving CR rates.

Item Type:Article
ID Code:4423
Status:Published
Refereed:Yes
Uncontrolled Keywords:Acute lymphocytic-leukemia, acute myeloid-leukemia, p-glycoprotein p-170, clinical-significance, multidrug-resistance, prognostic factors, cytogenetic abnormalities, homozygous deletions, cd34 expression, rap1gds1 genes
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 03 Istituti > Ematologia
Publisher:American Society of Hematology
eISSN:1528-0020
Additional Information:Prepublished online as a Blood First Edition Paper on September 22, 2005
Deposited On:31 Aug 2010 17:38

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