Fozza, Claudio and Nadal, Elisabet and Longinotti, Maurizio Roberto and Dazzi, Francesco (2007) T-cell receptor repertoire usage after allografting differs between CD4+CD25+ regulatory T cells and their CD4+CD25- counterpart. Haematologica, Vol. 92 (2), p. 206-214. eISSN 1592-8721. Article.
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Background and Objectives: After allogeneic haematopoietic stem cell transplantation (SCT) the whole T-cell receptor (TCR) repertoire shows a markedly skewed pattern for 2–3 years. A small fraction of CD4+T cells is represented by CD25+ regulatory lymphocytes (Treg), which play a crucial role in modulating peripheral tolerance. To investigate their ability to react to the massive antigenic stimulation generated in an allogeneic host, which could significantly affect their pattern of reconstitution, we analyzed the TCR repertoire of Treg after SCT, focusing on the degree of similarity to CD4+CD25-conventional T cells (Tconv).
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