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Coenzyme Q10 vitreous levels after administration of coenzyme Q10 eyedrops in patients undergoing vitrectomy

Fato, Romana and Bergamini, Christian and Leoni, Serena and Pinna, Antonio <1963- > and Carta, Francesco and Cardascia, Nicola and Micelli Ferrari, Tommaso and Sborgia, Carlo and Lenaz, Giorgio (2010) Coenzyme Q10 vitreous levels after administration of coenzyme Q10 eyedrops in patients undergoing vitrectomy. Acta Ophthalmologica Scandinavica, Vol. 88 (4), p. 150-151. eISSN 1600-0420. Article.

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DOI: 10.1111/j.1755-3768.2009.01632.x

Abstract

Coenzyme Q (ubiquinone, CoQ10) is an essential electron carrier in the mitochondrial respiratory chain. It is located mainly in the inner mitochondrial membrane, but is also present in serum lipoproteins, endomembranes and the plasma membrane of eukaryotic cells (Turunen et al. 2004). CoQ10 is also a redox component of electron transport chains in extramitochondrial membranes, where it acts as a powerful antioxidant and membrane stabilizer. Indirect evidence also points out that CoQ10 may be a useful therapeutic agent in ocular diseases where oxidative stress and apoptotic cell death are important pathogenic factors (Dunlop & Dunlop 1995; Blasi et al. 2001). The purpose of this study was to assess the intraocular penetration of CoQ10 by determining its vitreous concentration in patients treated with a commercially available topical eye preparation (Coqun® eyedrops; Visufarma SpA, Rome, Italy) and in untreated patients.

Item Type:Article
ID Code:4418
Status:Published
Refereed:Yes
Uncontrolled Keywords:Cogun, eye drops, hyaluronic acid, tocofersolan, ubidecarenone, unclassified drug
Subjects:Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Divisions:001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
Publisher:Blackwell
eISSN:1600-0420
Copyright Holders:Journal compilation © 2009 Acta Ophthalmol
Deposited On:31 Aug 2010 18:01

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