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Recurrent giant chalazia in hyperimmunoglobulin E (Job’s) syndrome

Patteri, Pierpaolo and Serru, Alain and Chessa, Maria Letizia and Loi, Michele and Pinna, Antonio <1963- > (2009) Recurrent giant chalazia in hyperimmunoglobulin E (Job’s) syndrome. International Ophthalmology, Vol. 29 (5), p. 415-417. eISSN 1573-2630. Article.

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DOI: 10.1007/s10792-008-9238-y


Hyperimmunoglobulinemia E (Job’s) syndrome is a rare autosomal dominant disorder appearing early in life with recurrent skin and pulmonary infections, characterized by markedly increased serum immunoglobulin E (IgE) levels. We describe a 50-year-old man with a 4-year history of recurrent, multiple giant chalazia in all eyelids. Medications and surgical intervention had produced only transient improvement. The patient had also had pulmonary and scalp infection. Laboratory tests disclosed elevated serum IgE (>1,000 IU/ml) and eosinophilia. As a result, based on the patient’s history and clinical and laboratory findings, a diagnosis of Job’s syndrome was made. Even though rarely, recurrent multiple giant chalazia may occur as an ophthalmic feature of Job’s syndrome. Hyperimmunoglobulinemia E syndrome should be suspected in any case of recurrent giant chalazia, regardless of the patient’s age. Measurement of serum IgE and eosinophils, along with internal evaluation, is essential to establish a proper diagnosis.

Item Type:Article
ID Code:4414
Uncontrolled Keywords:Hyperimmunoglobulinemia E, job’s syndrome, recurrent giant chalazia, middle-age
Subjects:Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Divisions:001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL3, Nuoro > Ospedale "San Francesco" > Reparto di Oculistica
Publisher:Springer Netherlands
Copyright Holders:© Springer Science+Business Media B.V. 2008
Deposited On:30 Aug 2010 13:58

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