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Plasma homocysteine and cysteine levels in retinal vein occlusion

Pinna, Antonio <1963- > and Carru, Ciriaco and Zinellu, Angelo and Dore, Stefano and Deiana, Luca and Carta, Francesco (2006) Plasma homocysteine and cysteine levels in retinal vein occlusion. Investigative Ophthalmology and Visual Science, Vol. 47 (9), p. 4067-4071. eISSN 1552-5783. Article.

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DOI: 10.1167/iovs.06-0290

Abstract

PURPOSE. To determine plasma homocysteine and cysteine levels in patients with retinal vein occlusion (RVO) and in healthy subjects and to ascertain whether there are statistically significant differences between patients and control subjects. METHODS. In this case-control study, the study group consisted of 75 consecutive patients with RVO: 33 had central retinal vein occlusion (CRVO), and 42 had branch retinal vein occlusion (BRVO). Seventy-two apparently healthy age- and sex-matched subjects served as control subjects. Homocysteine and cysteine levels were measured with a new laser-induced fluorescence capillary electrophoresis (CE-LIF) method. Wilcoxon or Student's t-test was used, when appropriate, to determine differences between groups. RESULTS. There were no significant differences in median plasma homocysteine between patients with RVO and control subjects, nor were there any statistically significant differences when patients were categorized by type of vein occlusion (CRVO or BRVO). Similarly, there were no significant differences in mean plasma cysteine between patients with RVO and control subjects. However, when categorized by type of vein occlusion, mean plasma cysteine was significantly higher in CRVO patients than in control subjects (P) = 0.034. CONCLUSIONS. This study failed to demonstrate an association between increased plasma homocysteine and RVO. Mean plasma cysteine was significantly higher in patients with CRVO, suggesting that hypercysteinemia may contribute to the pathogenesis of this retinal vascular disorder.

Item Type:Article
ID Code:4413
Status:Published
Refereed:Yes
Uncontrolled Keywords:Containing amino-acids, risk-factor, vascular-disease, reductase c677t, hyperhomocysteinemia, mutation, hyperhomocyst(e)inemia, autoxidation, metabolism, infarction
Subjects:Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
Publisher:Association for Research in Vision and Ophthalmology
eISSN:1552-5783
Copyright Holders:© Association for Research in Vision and Ophthalmology
Deposited On:30 Aug 2010 13:57

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