Dazzi, Francesco and Fozza, Claudio (2007) Reply to ‘Splenectomy status of the patient may have impact on response to donor lymphocyte infusions’ by Duygu Uckan-Çetinkaya et al. Leukemia, Vol. 21 (9), p. 2050-2051. eISSN 1476-5551. Article.
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We read with interest the recent letter to the editor by Uckan-Çetinkaya et al. concerning an article we have recently published in this journal. In this report, we investigated the factors affecting the dose required to achieve remission (effective cell dose (ECD)) in patients with chronic myeloid leukemia (CML) treated with donor lymphocyte infusions (DLI) in an escalating dose regimen (EDR), concluding that the response to DLI is dose dependent and that the main factors influencing the ECD are the disease stage at relapse and the degree of donor–recipient histocompatibility.
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