Reply to ‘Splenectomy status of the patient may have impact on response to donor lymphocyte infusions’ by Duygu Uckan-Çetinkaya et al.

Dazzi, Francesco and Fozza, Claudio (2007) Reply to ‘Splenectomy status of the patient may have impact on response to donor lymphocyte infusions’ by Duygu Uckan-Çetinkaya et al. Leukemia, Vol. 21 (9), p. 2050-2051. eISSN 1476-5551. Article.

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DOI: 10.1038/sj.leu.2404804

Abstract

We read with interest the recent letter to the editor by Uckan-Çetinkaya et al. concerning an article we have recently published in this journal. In this report, we investigated the factors affecting the dose required to achieve remission (effective cell dose (ECD)) in patients with chronic myeloid leukemia (CML) treated with donor lymphocyte infusions (DLI) in an escalating dose regimen (EDR), concluding that the response to DLI is dose dependent and that the main factors influencing the ECD are the disease stage at relapse and the degree of donor–recipient histocompatibility.

Item Type:	Article
ID Code:	4410
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Acute graft versus host disease, allograft, cancer staging, chronic myeloid leukemia, disease association, donor lymphocyte infusion, donor selection, graft versus leukemia effect, high risk patient, histocompatibility, leukemia relapse, leukemia remission, risk factor, splenectomy, treatment response
Subjects:	Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:	001 Università di Sassari > 03 Istituti > Ematologia
Publisher:	Nature Publishing Group
eISSN:	1476-5551
Deposited On:	31 Aug 2010 17:35

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