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Transplantation of sheep embrionic stem cells in cartilage lesions: preliminary observations

Rocca, Stefano and Antuofermo, Elisabetta and Dattena, Maria and Manunta, Maria Lucia Gabriella M. and Pilichi, Susanna and Meloni, Floriana and Leoni, Antonio (2007) Transplantation of sheep embrionic stem cells in cartilage lesions: preliminary observations. In: 4. Congresso nazionale A.I.P.Vet.: atti, 24-25 Maggio 2007, Alberese, Italia. Milano, AIPVet. p. 49. ISSN 1825-2265. Conference or Workshop Item.

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Abstract

Once damaged, joint cartilage never completely regenerates. This is due to absence of vascularisation, slow cellular turnover and impossibility for inflammation mediators to reach the cartilage lesion. Even small lesions involve alteration in joint functionality and can cause invalidating pathologies. Treatment is complex and the surgical techniques used to repair the joint surfaces do not give satisfactory and durable results because the new tissue produced is fibrous cartilage. The aim of this study is to evaluate whether ovine embryonic stem cells transplanted in experimental lesions can differentiate into chondrocyte cells and if the new cartilage is of ialine type. For that purpose, we used the ovine species. The evaluation of reparative tissue was performed 1, 2 and 6 months after cell inoculation with histological, immunohistochemical and in situ hybridization methods. Bare lesions and Tissucol-implanted lesions were used as controls. Results confirm the stem origin of the reparative tissue with stem cells differentiating prevalently into chondrocytes and rarely into fibrocytes.

Item Type:Conference or Workshop Item (Lecture)
ID Code:4407
Status:Published
Uncontrolled Keywords:Ovine embryonic stem cell, in situ hybridization, immunohistochemistry
Subjects:Area 07 - Scienze agrarie e veterinarie > AGR/09 Meccanica agraria
Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:001 Università di Sassari > 01 Dipartimenti > Patologia e clinica veterinaria
002 Altri enti e centri di ricerca del Nord Sardegna > AGRIS Sardegna, Olmedo
Publisher:AIPVet
ISSN:1825-2265
Deposited On:30 Aug 2010 10:01

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