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Disease relapse after haematopoietic stem cell transplantation: risk factors and treatment

Dazzi, Francesco and Fozza, Claudio (2007) Disease relapse after haematopoietic stem cell transplantation: risk factors and treatment. Best Practice & Research Clinical Haematology, Vol. 20 (2), p. 311-327. ISSN 1521-6926. Article.

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DOI: 10.1016/j.beha.2006.10.002


Disease relapse is the commonest cause of treatment failure after allogeneic haematopoietic stem-cell transplantation. Adoptive immunotherapy based on donor lymphocyte infusions (DLI) has a prominent role in the management of disease recurrence. Although the highest remission rates are achieved in chronic myeloid leukaemia (CML), encouraging results have also been reported in chronic lymphoproliferative disorders. However, the experience of DLI in CML is not necessarily applicable to the management of lymphoproliferative diseases because of the heterogeneity of the conditioning regimens used in chronic lymphoid malignancies. We will review the role of DLI for different disease types in the context of conventional and reduced-intensity conditioning regimens. The factors influencing response and graft-versus-host disease as well as the optimal cell dose will be discussed. Finally, we will describe the main avenues currently being explored to improve the selectivity and efficacy of DLI.

Item Type:Article
ID Code:4405
Uncontrolled Keywords:Allogeneic haematopoietic stem-cell transplantation, relapse, adoptive immunotherapy, donor lymphocyte infusions
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 03 Istituti > Ematologia
Copyright Holders:© 2006 Elsevier
Deposited On:31 Aug 2010 17:34

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