Ferranti, Pasquale and Barone, Francesca and Pucci, Pietro and Malorni, Antonio and Marino, Gennaro and Pilo, G. and Manca, Laura and Masala, Bruno Lucio (1994) Hb F-Sassari: A Novel Gγ Variant with a Threonine Residue at Position γ75, Characterized by Mass Spectrometry Techniques. Hemoglobin, Vol. 18 (4-5), p. 307-315. eISSN 1532-432X. Article.
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The cord blood sample of a Caucasian newborn contained about 40% of an abnormal fetal hemoglobin. The mutated γ chain was isolated using reversed phase high performance liquid chromatography and characterized by means of electrospray and fast atom bombardment mass spectrometric techniques as a Gγ-globin variant with an Ile->Thr substitution at position -γ75. The variant chain shows the same structure as the previously described Hb F-Charlotte that was demonstrated to be an Aγ variant with an Ile->Thr substitution at position γ75 and an additional Ala->Gly substitution at γ136. P. , F. Barone, P. Pucci, A. Malorni, G. Marino, G. Pilo, L. Manca, B. Masaia
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