Hb F-Sassari: A Novel Gγ Variant with a Threonine Residue at Position γ75, Characterized by Mass Spectrometry Techniques

Ferranti, Pasquale and Barone, Francesca and Pucci, Pietro and Malorni, Antonio and Marino, Gennaro and Pilo, G. and Manca, Laura and Masala, Bruno Lucio (1994) Hb F-Sassari: A Novel Gγ Variant with a Threonine Residue at Position γ75, Characterized by Mass Spectrometry Techniques. Hemoglobin, Vol. 18 (4-5), p. 307-315. eISSN 1532-432X. Article.

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DOI: 10.3109/03630269408996196

Abstract

The cord blood sample of a Caucasian newborn contained about 40% of an abnormal fetal hemoglobin. The mutated γ chain was isolated using reversed phase high performance liquid chromatography and characterized by means of electrospray and fast atom bombardment mass spectrometric techniques as a Gγ-globin variant with an Ile->Thr substitution at position -γ75. The variant chain shows the same structure as the previously described Hb F-Charlotte that was demonstrated to be an Aγ variant with an Ile->Thr substitution at position γ75 and an additional Ala->Gly substitution at γ136. P. , F. Barone, P. Pucci, A. Malorni, G. Marino, G. Pilo, L. Manca, B. Masaia

Item Type:	Article
ID Code:	4400
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Case report, chromatography high pressure liquid, fetal blood, globins, hemoglobins abnormal, human, infant newborn, Italy, peptide mapping, point mutation, spectrum analysis mass
Subjects:	Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
Publisher:	Taylor & Francis
eISSN:	1532-432X
Deposited On:	30 Aug 2010 13:56

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