UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Further ivestigations into the relationship between the dopanminergic system ascorbic acid and uric acid in the rat striatum

Desole, Maria Speranza and Miele, Maddalena and Esposito, Giovanni and Enrico, Paolo and Fresu, Luigia Grazia and De Natale, Guglielmo and Miele, Egidio (1991) Further ivestigations into the relationship between the dopanminergic system ascorbic acid and uric acid in the rat striatum. European Journal of Pharmacology, Vol. 205 (1), p. 97-100. eISSN 1879-0712. Article.

Full text not available from this repository.

DOI: 10.1016/0014-2999(91)90777-N

Abstract

Levels of dopaminc (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA), dehydroascorbic acid (DHAA), and uric acid were determined in the rat striatum following single apomorphine (1 mg/kg), scopolamine (0.6 mg/kg), pilocarpine (4 mg/kg), or pilocarpine + scopolamine (4 and 0.6 mg/kg, respectively) injections. The decrease in DOPAC levels and in the DOPAC/DA ratio, induced by the pharmacological manipulation, was linearly correlated with the increase in DHAA levels (r = −0.9060, P < 0.05) and with the increase in the DHAA/AA ratio (r = −0.9004, P < 0.05), respectively. I dopaminergic activaction or cholinergic inhibition both increase striatal AA oxidation, which is correlated with a decrease in DA turnover.

Item Type:Article
ID Code:4384
Status:Published
Refereed:Yes
Uncontrolled Keywords:Dopamine turnover ascorbate, apomorphine, scopolamine, striatum, (rat)
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Elsevier Science
eISSN:1879-0712
Copyright Holders:© 1991 Published by Elsevier Science B.V.
Deposited On:26 Aug 2010 13:55

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page