Desole, Maria Speranza and Miele, Maddalena and Esposito, Giovanni and Enrico, Paolo and Fresu, Luigia Grazia and De Natale, Guglielmo and Miele, Egidio (1991) Further ivestigations into the relationship between the dopanminergic system ascorbic acid and uric acid in the rat striatum. European Journal of Pharmacology, Vol. 205 (1), p. 97-100. eISSN 1879-0712. Article.
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Levels of dopaminc (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA), dehydroascorbic acid (DHAA), and uric acid were determined in the rat striatum following single apomorphine (1 mg/kg), scopolamine (0.6 mg/kg), pilocarpine (4 mg/kg), or pilocarpine + scopolamine (4 and 0.6 mg/kg, respectively) injections. The decrease in DOPAC levels and in the DOPAC/DA ratio, induced by the pharmacological manipulation, was linearly correlated with the increase in DHAA levels (r = −0.9060, P < 0.05) and with the increase in the DHAA/AA ratio (r = −0.9004, P < 0.05), respectively. I dopaminergic activaction or cholinergic inhibition both increase striatal AA oxidation, which is correlated with a decrease in DA turnover.
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