Vitale, Gabriella and Corona, Paola and Loriga, Mario and Carta, Antonio and Paglietti, Giuseppe and Ibba, Cristina and Giliberti, Gabriele and Loddo, Roberta and Marongiu, Esther and La Colla, Paolo (2010) Styrylbenzimidazoles: synthesis and biological activity: part 3. Medicinal Chemistry, Vol. 6 (2), p. 70-78. ISSN 1573-4064. Article.
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As a follow up of an anti-Flaviviridae project, a new series of variously substituted 2-styryl-benzimidazoles were synthesized and tested in vitro for biological activity.
Compounds were tested in cell-based assays against viruses representative of: i) two of the three genera of the Flaviviridae family, i.e. Pestiviruses and Flaviviruses; ii) other RNA virus families, such as Retroviridae, Picornaviridae, Paramyxoviridae, Rhabdoviridae and Reoviridae; iii) two DNA virus families (Herpesviridae and Poxviridae) as well as for cytotoxicity tests, run in parallel with antiviral assays,against MDBK, BHK and Vero 76 cells.
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