Cholesterol levels in HIV–HCV infected patients treated with lopinavir/r: results from the SCOLTA project

De Socio, Giuseppe Vittorio Luigi and Bonfanti, Paolo and Ricci, Elena and Orofino, Giancarlo and Madeddu, Giordano and Penco, Giovanni and Gianelli, Erika and Martinelli, Canio and Carradori, Silvia and Quirino, Tiziana and Rizzardini, Giuliano (2008) Cholesterol levels in HIV–HCV infected patients treated with lopinavir/r: results from the SCOLTA project. Biomedicine & Pharmacotherapy, Vol. 62 (1), p. 16-20. ISSN 0753-3322. Article.

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DOI: 10.1016/j.biopha.2007.07.012

Abstract

Background. It is not known whether antiretroviral therapy (ART) including lopinavir/r has a different effect on the lipid metabolism in HIV patients co-infected with HCV. This study investigated changes in lipid levels, comparing patients with HIV infection alone and those with HCV too, in the lopinavir/r cohort of the SCOLTA project.
Methods. We analyzed the data for the lopinavir/r nationwide cohort from 25 Italian infectious disease departments, which comprises 743 HIV-infected patients followed prospectively, comparing subjects with HIV–HCV co-infection and those with single-infection.
Results. At enrolment, co-infected patients had significantly lower mean cholesterol than HCV negative cases (162 ± 43 mg/dL vs. 185 ± 52 mg/dL, p = 0.0009). Total and non-HDL cholesterol and triglycerides rose significantly from baseline in HIV single-infection patients, but not in those with co-infection. The patients with dual HIV–HCV infection, treated with an ART regimen including lopinavir/r, have only limited increases in total and non-HDL cholesterol and triglycerides.
Conclusions. Changes in serum lipids in co-infected patients differed significantly from those in patients without HCV. It remains to be seen whether this is associated with a lower risk of progression of atherosclerotic disease.

Item Type:	Article
ID Code:	4295
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Antiretroviral therapy, lopinavir, HIV, atherosclerosis, HCV, cardiovascular diseases, cholesterol, lipids
Subjects:	Area 06 - Scienze mediche > MED/10 Malattie dell'apparato respiratorio
Divisions:	001 Università di Sassari > 03 Istituti > Malattie infettive e parassitarie
Publisher:	Elsevier Masson
ISSN:	0753-3322
Additional Information:	Fra gli autori è presente un gruppo di ricerca: CISAI Study Group, Milano.
Deposited On:	28 Jul 2010 18:00

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