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Is metabolic syndrome associated to HIV infection per se? Results from the HERMES study

Bonfanti, Paolo and De Socio, Giuseppe Vittorio Luigi and Marconi, Patrizia and Franzetti, Marzia and Martinelli, Canio and Vichi, Francesca and Penco, Giovanni and Madeddu, Giordano and Orofino, Giancarlo and Valsecchi, Laura and Vitiello, Paola and Menzaghi, Barbara and Magni, Carlo Alberto and Ricci, Elena (2010) Is metabolic syndrome associated to HIV infection per se? Results from the HERMES study. Current HIV Research, Vol. 8 (2), p. 165-171. ISSN 1570-162X. Article.

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DOI: 10.2174/157016210790442731

Abstract

HERMES is a prospective study, including all treatment-naive patients attending scheduled visits at hospitals in the CISAI group in 2007. The present cross-sectional analysis aims to assess the baseline prevalence and characteristics of Metabolic Syndrome (MS) in a population of HIV-positive treatment-naive patients. MS was diagnosed using the National Cholesterol Education Program (NCEP) definitions.
A total of 292 subjects were enrolled, median age was 37 years, 75% of them were males. The prevalence of MS was 12.3%. The most frequent trio of abnormalities that led to the diagnosis of MS was high blood pressure, triglycerides and HDL. Univariate analysis showed that MS was associated with the following variables: age, education, physical activity, advanced HIV disease (CDC stage C or HIV-RNA >100,000 copies + CD4 <100 cells/mm3). Higher educational levels remained protectively associated with MS in multivariate analysis. A higher risk of MS was also associated with advanced HIV disease.
Actually, treatment-naïve HIV-positive patients in an advanced stage of the disease have a higher prevalence of abnormal levels of triglycerides, HDL cholesterol and blood glucose than those at a less advanced stage. These findings of the HERMES study suggest, therefore, that HIV infection per se is associated to MS.

Item Type:Article
ID Code:4291
Status:Published
Refereed:Yes
Uncontrolled Keywords:HIV, naive, advanced HIV disease, metabolic syndrome, cardiovascular risk
Subjects:Area 06 - Scienze mediche > MED/10 Malattie dell'apparato respiratorio
Divisions:001 Università di Sassari > 03 Istituti > Malattie infettive e parassitarie
Publisher:Bentham Science
ISSN:1570-162X
Deposited On:28 Jul 2010 12:50

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