Coronnello, Marcella and Mini, Enrico and Caciagli, Barbara and Cinellu, Maria Agostina and Bindoli, Alberto and Gabbiani, Chiara and Messori, Luigi (2005) Mechanisms of cytotoxicity of selected organogold(III) compounds. Journal of Medicinal Chemistry, Vol. 48 (21), p. 6761-6765. eISSN 1520-4804. Article.
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The effects of a few cytotoxic organogold(III) compounds on ovarian A2780 human cancer cells were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced significant antiproliferative effects and promoted apoptosis to a greater extent than platinum drugs while causing only modest cell cycle modifications. The mechanistic implications of these findings are discussed: mitochondrial pathways are proposed to be directly involved in the apoptotic process in relation to selective inhibition of thioredoxin reductase.
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