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Mechanisms of cytotoxicity of selected organogold(III) compounds

Coronnello, Marcella and Mini, Enrico and Caciagli, Barbara and Cinellu, Maria Agostina and Bindoli, Alberto and Gabbiani, Chiara and Messori, Luigi (2005) Mechanisms of cytotoxicity of selected organogold(III) compounds. Journal of Medicinal Chemistry, Vol. 48 (21), p. 6761-6765. eISSN 1520-4804. Article.

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DOI: 10.1021/jm050493o

Abstract

The effects of a few cytotoxic organogold(III) compounds on ovarian A2780 human cancer cells were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced significant antiproliferative effects and promoted apoptosis to a greater extent than platinum drugs while causing only modest cell cycle modifications. The mechanistic implications of these findings are discussed: mitochondrial pathways are proposed to be directly involved in the apoptotic process in relation to selective inhibition of thioredoxin reductase.

Item Type:Article
ID Code:4285
Status:Published
Refereed:Yes
Uncontrolled Keywords:Organogold(III), cytotoxicity, ovarian cancer
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:American Chemical Society
eISSN:1520-4804
Deposited On:27 Jul 2010 19:10

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