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Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33

Copeman, James B. and Cucca, Francesco and Hearne, Catherine M. and Cornall, Richard J. and Reed, Peter W. and Ronningen, Kjersti Skjold and Undlien, Dag Erik and Nisticò, Lorenza and Buzzetti, Raffaella and Tosi, Roberto and Pociot, Flemming and Nerup, Jørn and Cornélis, F. and Barnett, Anthony H. and Bain, Stephen Charles and Todd, John A. (1995) Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nature Genetics, Vol. 9 (1), p. 80-85. eISSN 1546-1718. Article.

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DOI: 10.1038/ng0195-80


The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage disequilibrium at 21 microsatellite marker loci, using 348 affected sibpair families and 107 simplex families. The microsatellite D2S152 was linked to, and associated with, disease in families from three different populations. Our evidence localizes a new diabetes susceptibility gene, IDDM7, to within two centiMorgans of D2S152. This places it in a region of chromosome 2q that shows conserved synteny with the region of mouse chromosome 1 containing the murine type 1 diabetes gene, Idd5. These results demonstrate the utility of polymorphic microsatellites for linkage disequilibrium mapping of genes for complex diseases.

Item Type:Article
ID Code:4269
Uncontrolled Keywords:Hl-a antigens, insulin gene, mellitus IDDM, polymorphism, region, determinants, resistance, receptor, repeat, dna
Subjects:Area 06 - Scienze mediche > MED/03 Genetica medica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Nature Publishing Group
Deposited On:26 Jul 2010 15:41

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