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Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes

Davies, June L. and Cucca, Francesco and Goy, Juliet V. and Atta, Zeinat A. A. and Merriman, Marilyn E. and Wilson, Amanda J. and Barnett, Anthony H. and Bain, Stephen Charles and Todd, John A. (1996) Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes. Human Molecular Genetics, Vol. 5 (7), p. 1071-1074. eISSN 1460-2083. Article.

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Linkage analysis of type 1 diabetes sib pair families (n = 334) has suggested two separate regions of human chromosome 6q are linked to disease (designated IDDM5 and IDDM8). To test if these are false positive results, all available sib pair families (n = 429) were typed using a 92% informative map of chromosome 6q and multipoint analysis. The two regions still showed positive evidence of linkage, most notably the proterminal region, 6q27, corresponding to IDDM8 (MLS = 2.57, p = 0.0006; λ(s) = 1.17). In addition, some evidence of transmission disequilibrium was seen with marker a046xa9 (IDDM5).

Item Type:Article
ID Code:4268
Uncontrolled Keywords:Insulin gene region, microsatellite loci, susceptibility gene, mellitus IDDM, disequilibrium, disease, traits
Subjects:Area 06 - Scienze mediche > MED/03 Genetica medica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Oxford University Press
Deposited On:26 Jul 2010 15:38

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