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Susceptibility to type 1 diabetes: genes and mechanisms

Contu, Daniela and Cucca, Francesco (2005) Susceptibility to type 1 diabetes: genes and mechanisms. In: Chiarelli, Francesco and Dahl-Jørgensen, Knut and Kiess, Wieland (eds). Diabetes in childhood and adolescence. Basel, Karger. p. 28-56. (Pediatric and adolescent medicine, 10). eISBN 978-3-318-01099-2. Book Section.

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DOI: 10.1159/000085777


Autoimmune diabetes can occur in rare monogenic disorders such as APECED (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy) and IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked), but it is more frequently inherited as a common multifactorial trait. The molecular bases of the two rare Mendelian forms of autoimmune diabetes, both characterized by a severe autoimmune pathology of several organs and tissues, have recently been clarified, providing key insights into some mechanisms leading to autoimmunity in humans and in mice.

Item Type:Book Section
ID Code:4265
Uncontrolled Keywords:Autoimmune diabetes, genetics
Subjects:Area 06 - Scienze mediche > MED/03 Genetica medica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Deposited On:23 Jul 2010 18:51

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