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Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and -DR4 alleles

Marrosu, Maria Giovanna and Murru, Maria Rita and Costa, Gianna and Cucca, Francesco and Sotgiu, Stefano and Rosati, Giulio and Muntoni, Francesco M. (1997) Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and -DR4 alleles. American Journal of Human Genetics, Vol. 61 (2), p. 454-457. eISSN 1537-6605. Article.

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The preponderance of genetic factors in attempts to account for susceptibility to multiple sclerosis (MS), a common inflammatory and demyelinating disease of young adults, has recently been demonstrated (Ebers et al. 1995). The inheritance of MS appears to be complex and is believed to involve several genes (Ebers et al. 1996; The Multiple Sclerosis Genetics Group 1996; Sawcer et al. 1996). Methodological approaches to the study of genes conferring susceptibility to MS include association studies, which measure the frequency of a specific allele in affected and healthy populations, and linkage studies, which trace the inheritance of a gene from parents and correlate these genes to disease susceptibility.

Item Type:Article
ID Code:4253
Uncontrolled Keywords:Dependent diabetes-mellitus, HLA, haplotype, genes, Sardinia
Subjects:Area 06 - Scienze mediche > MED/03 Genetica medica
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Cell Press / Elsevier
Copyright Holders:© 1997 by The American Society of Human Genetics
Deposited On:26 Jul 2010 12:58

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