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Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11

Reed, Peter W. and Cucca, Francesco and Jenkins, Suzanne C. and Merriman, Marilyn E. and Wilson, Amanda J. and McKinney, Patricia A. and Bosi, Emanuele and Joner, Geir and Ronningen, Kjersti Skjold and Thorsby, Erik and Undlien, Dag Erik and Merriman, Tony R. and Barnett, Anthony H. and Bain, Stephen Charles and Todd, John A. (1997) Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11. Human Molecular Genetics, Vol. 6 (7), p. 1011-1016. eISSN 1460-2083. Article.

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Abstract

A region of linkage to type 1 diabetes has been defined on human chromosome 10p11-q11 (IDDM10; P= 0.0007) using 236 UK and 76 US affected sibpairs and a 1 cM resolution microsatellite marker map. Analysis by the transmission disequilibrium test (TDT) in 1159 families with at least one diabetic child, from the UK, the US, Norway Sardinia and Italy provided additional support for linkage at D10S193 (P = 0.006, P(c) = 0.17). Notably, 5.1 cM distal to D10S193, marker D10S588 also provided positive TDT results (P = 0.009, P(c) = 0.25) but the allele under analysis was also preferentially transmitted to nonaffected siblings (P= 0.0008, P(c)= 0.02). This allele was positively associated in an independent UK case control study and, importantly, was neutrally transmitted in control CEPH families. These results suggest a type 1 diabetes susceptibility locus on chromosome 10p11-q11 (provisionally designated IDDM10) and demonstrate the necessity of analysis of non affected siblings in disease families, as well as analysis of control families.

Item Type:Article
ID Code:4250
Status:Published
Refereed:Yes
Uncontrolled Keywords:Insulin gene region, linkage disequilibrium, mellitus, association, traits
Subjects:Area 06 - Scienze mediche > MED/03 Genetica medica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Oxford University Press
eISSN:1460-2083
Deposited On:26 Jul 2010 16:57

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