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Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster

Esposito, Laura and Hill, Natasha Jeremy and Pritchard, Lynn E. and Cucca, Francesco and Muxworthy, Claire and Merriman, Marilyn E. and Wilson, Amanda J. and Julier, Cécile and Delépine, Marc and Tuomilehto, Jaakko and Tuomilehto Wolf, Eva and Ionescu Tirgoviste, Constantin and Nisticò, Lorenza and Buzzetti, Raffaella and Pozzilli, Paolo and Ferrari, Maurizio and Bosi, Emanuele and Pociot, Flemming and Nerup, Jørn and Bain, Stephen Charles and Todd, John A. (1998) Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. Diabetes, Vol. 47 (11), p. 1797-1799. ISSN 0012-1797. Article.

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DOI: 10.2337/diabetes.47.11.1797

Abstract

In the spontaneous mouse model of type 1 diabetes, the nonobese (NOD) strain, a type 1 diabetes locus, Idd5, has been mapped to chromosome 1. Because mouse chromosome 1 shares a homologous 33-cM region between the genes col3a1 and col6a3 with human chromosome 2q31–q35 (data shown at http://www.ncbi.nlm.nih.gov/Omim/Homology/), several groups have searched chromosome 2 for loci affecting human type 1 diabetes. Previous studies have provided evidence for at least three type 1 diabetes loci (IDDM7, IDDM12, and IDDM13) within a 23-cM region of chromosome 2q31–q35. We have now evaluated linkage on chromosome 2, by multipoint analysis using Mapmaker/Sibs, of 34 microsatellite markers and an interleukin-1 (IL-1) TaqI polymorphism in 352 U.K. families.

Item Type:Article
ID Code:4245
Status:Published
Refereed:Yes
Uncontrolled Keywords:Linkage disequilibrium, susceptibility genes, mellitus IDDM, markers, region
Subjects:Area 06 - Scienze mediche > MED/03 Genetica medica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:American Diabetes Association
ISSN:0012-1797
Additional Information:Fra gli autori figura un gruppo di ricerca: the IMDIAB Study Group, Roma.
Deposited On:23 Jul 2010 10:11

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