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ICAM-1 gene is not associated with multiple sclerosis in Sardinian patients

Marrosu, Maria Giovanna and Schirru, Lucia and Fadda, Elisabetta and Mancosu, Cristina and Lai, Marina and Cocco, Eleonora and Cucca, Francesco (2000) ICAM-1 gene is not associated with multiple sclerosis in Sardinian patients. Journal of Neurology, Vol. 247 (9), p. 677-680. eISSN 1432-1459. Article.

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DOI: 10.1007/s004150070109

Abstract

An increased amount of the intercellular adhesion molecule (ICAM) 1 molecule has been found in the blood of actively relapsing multiple sclerosis (MS) patients, but is unclear whether this enhanced expression is partially causative of the MS process, or whether it is merely an epiphenomenon of the inflammatory-immunological reaction. Using the transmission disequilibrium test (TDT), we studied exon 4 and exon 6 polymorphism of the ICAM-1 gene from 157 families with both parents, one affected and one healthy sib coming from Sardinia, an Italian island having a high incidence and prevalence of MS. TDT did not show variation in the expected 50:50 frequency in transmission in either healthy or affected sibs, using phenotypic or genotypic analysis. Moreover, independence from the predisposing HLA-DRB1-DQA1-DQB1 haplotype was confirmed by TDT analysis performed on patients stratified according to the presence or absence of the HLA-DRB1, DQA1, DQB1 Sardinian predisposing haplotypes. Our data suggest that the increased expression of the ICAM-1 molecule observed in both blood and periplaque microvessels may be considered a consequence of the inflammatory process rather than the result of a genetic variation.

Item Type:Article
ID Code:4231
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple sclerosis, genetics, ICAM-1 gene, Sardinia
Subjects:Area 06 - Scienze mediche > MED/03 Genetica medica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Springer Berlin / Heidelberg
eISSN:1432-1459
Copyright Holders:© Steinkopff Verlag 2000
Deposited On:21 Jul 2010 10:53

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