Dahlman, Ingrid and Eaves, Iain A. and Kosoy, Roman and Morrison, V. Anne and Heward, Joanne and Gough, Stephen C.L. and Allahabadia, Amit and Franklyn, Jayne A. and Tuomilehto, Jaakko and Tuomilehto Wolf, Eva and Cucca, Francesco and Guja, Cristian and Ionescu Tirgoviste, Constantin and Stevens, Helen E. and Carr, Philippa and Nutland, Sarah and McKinney, Patricia A. and Shield, Julian P. and Wang, William and Cordell, Heather J. and Walker, Neil and Todd, John A. and Concannon, Patrick J. (2002) Parameters for reliable results in genetic association studies in common disease. Nature Genetics, Vol. 30 (2), p. 149-150. eISSN 1546-1718. Article.
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It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.
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