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The Co-inheritance of type 1 diabetes and multiple sclerosis in Sardinia cannot be explained by genotype variation in the HLA region alone

Marrosu, Maria Giovanna and Motzo, Costantino and Murru, Raffaele and Lampis, Rosanna and Costa, Gianna and Zavattari, Patrizia and Contu, Daniela and Fadda, Elisabetta and Cocco, Eleonora and Cucca, Francesco (2004) The Co-inheritance of type 1 diabetes and multiple sclerosis in Sardinia cannot be explained by genotype variation in the HLA region alone. Human Molecular Genetics, Vol. 13 (23), p. 2919-2924. eISSN 1460-2083. Article.

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DOI: 10.1093/hmg/ddh319

Abstract

compared with the surrounding southern European populations. Surprisingly, a 5-fold increased prevalence of T1D has also been observed in Sardinian MS patients. Susceptibility to both disorders is associated with common variants of the HLA-DRB1 and -DQB1 loci. In this study, we determined the relative contribution of genotype variation of these loci to the co-occurrence of the two disorders in Sardinia. We genotyped 1052 T1D patients and 1049 MS patients (31 of whom also had T1D) together with 1917 ethnically matched controls. On the basis of the absolute risks for T1D of the HLA-DRB1-DQB1 genotypes, we established that these loci would only contribute to a 2-fold increase in T1D prevalence in MS patients. From this evidence, we conclude that shared disease associations due to the HLA-DRB1-DQB1 loci provide only a partial explanation for the observed increased prevalence of T1D in Sardinian MS patients. The data suggest that variation at other non-HLA class II loci, and/or unknown environmental factors contribute significantly to the co-occurrence of these two traits.

Item Type:Article
ID Code:4198
Status:Published
Refereed:Yes
Uncontrolled Keywords:Experimental autoimmune encephalomyelitis, genetic-analysis, mellitus, disease, mice, susceptibility, association, population, loci haplotypes, Sardinia
Subjects:Area 06 - Scienze mediche > MED/03 Genetica medica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Oxford University Press
eISSN:1460-2083
Deposited On:16 Jul 2010 12:18

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