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HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease

Jores, Rita Désirée and Frau, Fulvia and Cucca, Francesco and Clemente, Maria Grazia and Orrù, Sandra and Rais, Marco and De Virgiliis, Stefano and Congia, Mauro (2007) HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease. Scandinavian Journal of Gastroenterology, Vol. 42 (1), p. 48-53. eISSN 1502-7708. Article.

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DOI: 10.1080/00365520600789859

Abstract

Objective. Celiac disease (CD) is a T-lymphocyte-mediated small intestinal enteropathy triggered and maintained by dietary gluten, with a strong genetic component mapping to the HLA genes encoding for the class II DQ(α1*0501, β1*02) molecule. Damage of the small intestine may cause a variety of clinical signs ranging from isolated long-standing iron-deficiency anemia refractory to iron supplementation to forms of severe malnutrition that may become life threatening. However, patients carrying the typical intestinal lesions of CD and presenting no symptoms at all (silent CD) are also a common clinical observation. Since it is commonly assumed that clinical signs and symptoms tend to correlate with the severity of the intestinal damage, the purpose of this study was to investigate whether particular HLA class II genotypes might also influence the extent of intestinal damage and consequently the clinical presentation of the disease. Material and methods. We retrospectively compared histological grading of celiac disease intestinal biopsies with HLA haplotype, age at onset of disease and clinical signs and symptoms. Results. Our findings showed that homozygosis for the DQB1*0201 allele is associated with a higher severity of the histological score (p<0.008). Of note for the clinician, this work also suggests that the same type 3c of intestinal damage causes a different clinical syndrome, depending on the patient's age. Conclusions. The genetic predisposition at the HLA-DQB1 locus influences the severity of the mucosal damage in a dose-dependent manner, but not the clinical presentation, of celiac disease.

Item Type:Article
ID Code:4193
Status:Published
Refereed:Yes
Uncontrolled Keywords:Celiac disease, HLA, intestinal mucosal atrophy
Subjects:Area 06 - Scienze mediche > MED/03 Genetica medica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Informa Healthcare
eISSN:1502-7708
Deposited On:16 Jul 2010 12:25

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