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Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat

Desole, Maria Speranza and Esposito, Giovanni and Migheli, Rossana and Fresu, Luigia Grazia and Sircana, Sara and Miele, Maddalena and De Natale, Guglielmo and Miele, Egidio (1995) Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat. Neuroscience Letters, Vol. 192 (2), p. 73-76. ISSN 0304-3940. Article.

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DOI: 10.1016/0304-3940(95)11613-2

Abstract

Levels of uric acid, xanthine, hypoxanthine, ascorbic acid (AA), dehydroascorbic acid, glutathione (GSH), noradrenaline (NA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and and 3-methoxytyramine were determined in the striatum and/or in the brainstem of 3-month-old male Wistar rats given manganese (MnCl2, 200 mg/kg/day for 7 days by gavage) alone or associated with allopurinol. Allopurinol alone (300 mg/kg/day for 4 days by gavage) decreased uric acid and increased xanthine levels both in the striatum and in the brainstem; moreover, allopurinol decreased the striatal DOPAC + HVA/DA ratio. Allopurinol antagonised the Mn-induced: (a) increase in the DOPAC + HVA/DA ratio; (b) increase in uric acid levels and AA oxidation; and (c) decrease in GSH and NA levels. We conclude that allopurinol may protect against Mn-induced oxidative stress by inhibiting both DA oxidative metabolism and xanthine oxidase-mediated formation of reactive oxygen species.

Item Type:Article
ID Code:4168
Status:Published
Refereed:Yes
Uncontrolled Keywords:Manganese, neuronal oxidative stress, allopurinol, xanthine oxidase, uric acid, rat
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Elsevier Science Ireland
ISSN:0304-3940
Deposited On:14 Jul 2010 13:50

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