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Improvement of antiamoebic activity of Rokitamycin loaded in chitosan microspheres

Rassu, Giovanna and Gavini, Elisabetta and Mattana, Antonella and Giunchedi, Paolo (2008) Improvement of antiamoebic activity of Rokitamycin loaded in chitosan microspheres. The Open Drug Delivery Journal, Vol. 2 , p. 38-43. ISSN 1874-1266. Article.

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DOI: 10.2174/1874126600802010038

Abstract

Rokitamycin is a new macrolide containing 16 carbon atoms, strongly inhibitory for Acanthamoeba castellanii, an opportunistic protozoa of humans which cause primarily amoebic keratitis and chronic, but fatal, amoebic granulomatous meningoencephalitis. Chitosan microspheres were prepared as carriers to obtain a controlled release of rokitamycin, able to improve the antiamoebic activity of this drug. The microparticles were in vitro characterised and the efficacy of rokitamycin alone and encapsulated into microspheres on the growth rate of Acanthamoeba castellani was evaluated. The results obtained suggest that spray-drying is a good technique for the preparation of microspheres loaded with rokitamycin. The loading of the drug into the polymeric network leads to an increase in the dissolution rate compared to drug raw material and improves and prolongs the in vitro antiamoebic activity of the drug. Thus, microspheres based on rokitamycin could be used in the therapy of systemic and topical infections caused by Acanthamoeba.

Item Type:Article
ID Code:4110
Status:Published
Refereed:Yes
Uncontrolled Keywords:Rokitamycin, chitosan microspheres, spray-drying, antiamoebic activity, Acanthamoeba castellanii
Subjects:Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Bentham Open
ISSN:1874-1266
Copyright Holders:© Rassu et al.; Licensee Bentham Open
Deposited On:08 Jul 2010 08:56

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