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Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer

Emanueli, Costanza and Salis, Maria Bonaria and Pinna, Alessandra and Stacca, Tiziana and Milia, Anna Franca and Spano, Alessandra and Chao, Julie and Chao, Lee and Sciola, Gian Luigi and Madeddu, Paolo Roberto (2002) Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer. Circulation, Vol. 106 (8), p. 993-999. eISSN 1524-4539. Article.

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DOI: 10.1161/01.CIR.0000027104.33206.C8

Abstract

Background. Microvascular insufficiency represents a major cause of end-organ failure among diabetics.
Methods and Results. In streptozotocin-induced diabetic mice, we evaluated the potential of human tissue kallikrein (hTK) gene as a sole therapy against peripheral microangiopathy. Local delivery of hTK gene halted the progression of microvascular rarefaction in hindlimb skeletal muscle by inhibiting apoptosis, thus ensuring an improved hemodynamic recovery in case of supervening vascular occlusion. The curative action of hTK did not necessitate insulin supplementation. Application of gene therapy at a stage of established microangiopathy stimulated vascular regeneration.
Conclusions. Our studies indicate that hTK may represent a useful tool for the treatment of microvascular complications in diabetics.

Item Type:Article
ID Code:4042
Status:Published
Refereed:Yes
Uncontrolled Keywords:Diabetes mellitus, microangiopathy, gene therapy, angiogenesis, apoptosis
Subjects:Area 05 - Scienze biologiche > BIO/06 Anatomia comparata e citologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
002 Altri enti e centri di ricerca del Nord Sardegna > National laboratory of the national institute of biostructures and biosystems, Osilo > Cardiovascular medicine and gene therapy Section
Publisher:Lippincott Williams & Wilkins
eISSN:1524-4539
Copyright Holders:© 2002 American Heart Association
Deposited On:18 Jun 2010 12:53

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