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Long-term survival and intracellular replication of Mycoplasma hominis in Trichomonas vaginalis cells: potential role of the protozoon in transmitting bacterial infection

Dessì, Daniele and Delogu, Giuseppe and Emonte, Eleonora and Catania, Maria Rosaria and Fiori, Pier Luigi and Rappelli, Paola (2005) Long-term survival and intracellular replication of Mycoplasma hominis in Trichomonas vaginalis cells: potential role of the protozoon in transmitting bacterial infection. Infection and Immunity, Vol. 73 (2), p. 1180-1186. eISSN 1098-5522. Article.

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DOI: 10.1128/IAI.73.2.1180-1186.2005

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Abstract

The existence of a symbiotic relationship between Trichomonas vaginalis and Mycoplasma hominis, which is the first reported example of symbiosis between two obligate human pathogens, has been recently reported by our research group. In this work, we examined the cellular location of M. hominis in respect to T. vaginalis. By using gentamicin protection assays, double immunofluorescence, and confocal microscopy, we obtained strong evidence that M. hominis is located within protozoan cells. 5-Bromodeoxyuridine incorporation assays showed that intracellularly located mycoplasmas actively synthesize DNA. Our results demonstrate that M. hominis has the capability of entering trichomonad cells and of replicating inside the protozoon. These findings suggest that symbiosis might provide the bacteria, during human infection, with the capability to resist to environmental stresses, such as host defense mechanisms and pharmacological therapies.

Item Type:Article
ID Code:4040
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycoplasma hominis, Trichomonas vaginalis, protozoan cells
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:American Society for Microbiology
eISSN:1098-5522
Deposited On:18 Jun 2010 12:16

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