Messori, Luigi and Marcon, Giordana and Cinellu, Maria Agostina and Coronnello, Marcella and Mini, Enrico and Gabbiani, Chiara and Orioli, Pierluigi (2004) Solution chemistry and cytotoxic properties of novel organogold(III) compounds. Bioorganic & Medicinal Chemistry, Vol. 12 (23), p. 6039-6043. ISSN 0968-0896. Article.
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The solution behaviour of some novel organogold(III) compounds was investigated, and their cytotoxic properties evaluated against a few human tumour cell lines (A2780/S, A2780/R, MCF7, HT29 and A549). Specifically, the following compounds were considered: [Au(bipydmb-H)(2,6-xylidine-H)][PF6] (AuXyl) and [Au(bipydmb-H)(p-toluidine-H)][PF6] (AuTol) (in which bipydmb = 6-(1,1-dimethylbenzyl)-2,2′-bipyridine), [Au(pydmb-H)(AcO)2] (AuPyAcO) (in which pydmb = 2-(1,1-dimethylbenzyl)-pyridine) and [Au(pzPh-H)Cl3]K (AuPzCl) (in which pzPh = 1-phenylpyrazole). The solution chemistry of these compounds, under physiological-like conditions, was investigated through UV–vis absorption and 1H NMR spectroscopies. Significant cytotoxic effects in vitro were observed in selected cases.
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