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Solution chemistry and cytotoxic properties of novel organogold(III) compounds

Messori, Luigi and Marcon, Giordana and Cinellu, Maria Agostina and Coronnello, Marcella and Mini, Enrico and Gabbiani, Chiara and Orioli, Pierluigi (2004) Solution chemistry and cytotoxic properties of novel organogold(III) compounds. Bioorganic & Medicinal Chemistry, Vol. 12 (23), p. 6039-6043. ISSN 0968-0896. Article.

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DOI: 10.1016/j.bmc.2004.09.014

Abstract

The solution behaviour of some novel organogold(III) compounds was investigated, and their cytotoxic properties evaluated against a few human tumour cell lines (A2780/S, A2780/R, MCF7, HT29 and A549). Specifically, the following compounds were considered: [Au(bipydmb-H)(2,6-xylidine-H)][PF6] (AuXyl) and [Au(bipydmb-H)(p-toluidine-H)][PF6] (AuTol) (in which bipydmb = 6-(1,1-dimethylbenzyl)-2,2′-bipyridine), [Au(pydmb-H)(AcO)2] (AuPyAcO) (in which pydmb = 2-(1,1-dimethylbenzyl)-pyridine) and [Au(pzPh-H)Cl3]K (AuPzCl) (in which pzPh = 1-phenylpyrazole). The solution chemistry of these compounds, under physiological-like conditions, was investigated through UV–vis absorption and 1H NMR spectroscopies. Significant cytotoxic effects in vitro were observed in selected cases.

Item Type:Article
ID Code:4032
Status:Published
Refereed:Yes
Uncontrolled Keywords:Organogold(III) complexes, UV–vis absorption spectroscopy, 1H NMR spectroscopy, cytotoxicity, gold, cancer
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:Pergamon-Elsevier Science
ISSN:0968-0896
Copyright Holders:© 2004 Elsevier
Deposited On:17 Jun 2010 12:35

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