Abstract

The solution behaviour of some novel organogold(III) compounds was investigated, and their cytotoxic properties evaluated against a few human tumour cell lines (A2780/S, A2780/R, MCF7, HT29 and A549). Specifically, the following compounds were considered: [Au(bipy^dmb-H)(2,6-xylidine-H)][PF₆] (AuXyl) and [Au(bipy^dmb-H)(p-toluidine-H)][PF₆] (AuTol) (in which bipy^dmb = 6-(1,1-dimethylbenzyl)-2,2′-bipyridine), [Au(py^dmb-H)(AcO)₂] (AuPyAcO) (in which py^dmb = 2-(1,1-dimethylbenzyl)-pyridine) and [Au(pz^Ph-H)Cl₃]K (AuPzCl) (in which pzPh = 1-phenylpyrazole). The solution chemistry of these compounds, under physiological-like conditions, was investigated through UV–vis absorption and ¹H NMR spectroscopies. Significant cytotoxic effects in vitro were observed in selected cases.

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