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A Plant-specific cyclin-dependent kinase is involved in the control of G2/M progression in plants

Porceddu, Andrea and Stals, Hilde and Reichheld, Jean-Philippe and Segers, Gerda and De Veylder, Lieven and De Pinho Barrôco, Rosa and Casteels, Peter and Montagu, Marc van and Inzé, Dirk and Mironov, Vladimir A. (2001) A Plant-specific cyclin-dependent kinase is involved in the control of G2/M progression in plants. The Journal of Biological Chemistry, Vol. 276 (39), p. 36354-36360. eISSN 1083-351X. Article.

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DOI: 10.1074/jbc.M011060200

Abstract

Cyclin-dependent kinases (CDKs) control the key transitions in the eukaryotic cell cycle. All the CDKs known to control G2/M progression in yeast and animals are distinguished by the characteristic PSTAIRE motif in their cyclin-binding domain and are closely related. Higher plants contain in addition a number of more divergent non-PSTAIRE CDKs with still obscure functions. We show that a plant-specific type of non-PSTAIRE CDKs is involved in the control of the G2/M progression. In synchronized tobacco BY-2 cells, the corresponding protein, accumulated in a cell cycle-regulated fashion, peaking at the G2/M transition. The associated histone H1 kinase activity reached a maximum in mitosis and required a yet unidentified subunit to be fully active. Down-regulation of the associated kinase activity in transgenic tobacco plants using a dominant-negative mutation delayed G2/M transition. These results provide the first evidence that non-PSTAIRE CDKs are involved in the control of the G2/M progression in plants.

Item Type:Article
ID Code:4017
Status:Published
Refereed:Yes
Uncontrolled Keywords:Cyclin-dependent kinase (CDK), eukaryotic cell cycle, G2/M progression
Subjects:Area 07 - Scienze agrarie e veterinarie > AGR/07 Genetica agraria
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze agronomiche e genetica vegetale agraria
Publisher:The American Society for Biochemistry and Molecular Biology
eISSN:1083-351X
Deposited On:16 Jun 2010 11:05

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