Varoni, Maria Vittoria and Palomba, Domenico and Satta, Margherita and Satta, Andrea Ercole and Anania, Vittorio Domenico (2003) Different response of intracerebroventricular cadmium administration on blood pressure in normal and low urinary kallikrein rats. Pharmacological Research, Vol. 47 (2), p. 157-162. ISSN 1043-6618. Article.
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Cadmium intracerebroventricular (i.c.v.) administration, at definite concentrations, induces a dose-dependent increase in the systemic blood pressure. Kallikreins are suggested to be important regulators of cardiovascular function. We evaluated the effects of 10 μg i.c.v. cadmium on mean blood pressure (MBP) and several urinary parameters such as 24 h urine volume, sodium and potassium excretion and osmolality in a rat strain inbred for low urinary kallikrein and in normal-kallikrein Wistar rats. Low-kallikrein rats (LKR) showed an increase in MBP that, after an initial peak (27% from baseline), persisted higher than basal levels (10%) over 24 h. In normal-kallikrein rats (NKR) a different reaction of blood pressure to cadmium was observed, causing a temporary increase (26% from baseline) of the systemic blood pressure, that returned to normal values within 2 h.
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