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Different response of intracerebroventricular cadmium administration on blood pressure in normal and low urinary kallikrein rats

Varoni, Maria Vittoria and Palomba, Domenico and Satta, Margherita and Satta, Andrea Ercole and Anania, Vittorio Domenico (2003) Different response of intracerebroventricular cadmium administration on blood pressure in normal and low urinary kallikrein rats. Pharmacological Research, Vol. 47 (2), p. 157-162. ISSN 1043-6618. Article.

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DOI: 10.1016/S1043-6618(02)00286-4


Cadmium intracerebroventricular (i.c.v.) administration, at definite concentrations, induces a dose-dependent increase in the systemic blood pressure. Kallikreins are suggested to be important regulators of cardiovascular function. We evaluated the effects of 10 μg i.c.v. cadmium on mean blood pressure (MBP) and several urinary parameters such as 24 h urine volume, sodium and potassium excretion and osmolality in a rat strain inbred for low urinary kallikrein and in normal-kallikrein Wistar rats. Low-kallikrein rats (LKR) showed an increase in MBP that, after an initial peak (27% from baseline), persisted higher than basal levels (10%) over 24 h. In normal-kallikrein rats (NKR) a different reaction of blood pressure to cadmium was observed, causing a temporary increase (26% from baseline) of the systemic blood pressure, that returned to normal values within 2 h.
In addition, LKR showed a considerable reduction in the urinary volume (UV; 43.0±20 ml/24 h versus 13.2±6 ml/24 h, P < 0.006), with an increase in the urinary osmolality (UOsm; 500±210 mOsm/l versus 1391±245 mOsm/l, P < 0.0002). Sodium (UNa; 1761±432 μEq/24 h versus 1156±522 μEq/24 h, P < 0.03) and potassium excretion (UK; 2186±482 μEq/24 h versus 936±299 μEq/24 h, P < 0.0006) were both significantly reduced. No changes in UV, UOsm and UK were observed in normal urinary kallikrein rats with the exception of UNa excretion that was significantly increased (667±274 μEq/24 h versus 1725±300 μEq/24 h, P < 0.03).
These results suggest that a genetically determined defect in urinary kallikrein excretion leads to a different hypertensive response to i.c.v. cadmium and to a different renal excretion of electrolytes. Perhaps the differences of blood pressure response could be due, at least in part, to a different sensitivity of LKR to cadmium: this implies a complex and articulate hypertensive effect of cadmium involving more systems than those supposed so far.

Item Type:Article
ID Code:3994
Uncontrolled Keywords:Cadmium, kallikrein, blood pressure, intracerebroventricular
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/07 Farmacologia e tossicologia veterinaria
Area 05 - Scienze biologiche > BIO/15 Biologia farmaceutica
Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:001 Università di Sassari > 01 Dipartimenti > Biologia animale
001 Università di Sassari > 03 Istituti > Patologia speciale medica e metodologia clinica
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Academic Press / Elsevier
Copyright Holders:© 2002 Elsevier Science
Deposited On:10 Jun 2010 18:52

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