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Renal blood flow in hypercholesterolemic pigs is increased by chronic antioxidant treatment

De Nigris, Filomena and Demontis, Maria Piera and Rodriguez-Porcel, Martin and Anania, Vittorio Domenico and Lerman, Lilach O. and Napoli, Claudio (2003) Renal blood flow in hypercholesterolemic pigs is increased by chronic antioxidant treatment. Journal of Veterinary Pharmacology and Therapeutics, Vol. 26 (2), p. 113-116. eISSN 1365-2885. Article.

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DOI: 10.1046/j.1365-2885.2003.00461.x

Abstract

Oxygen radical species can influence vascular tone, and antioxidants may have hemodynamic and vascular effects. To date, the vascular effects of chronic intervention with a combination of antioxidant vitamins E and C on renal blood flow (RBF) in hypercholesterolemia (which increases oxidative stress) have not been fully defined. The aim of this intervention study was to explore the involvement of increased oxidative stress in pig RBF disturbance by using chronic dietary antioxidant vitamin intervention. Responses of RBF to the acetylcholine (Ach) were measured in vivo using electron beam computed tomography (EBCT). Acetylcholine significantly increased RBF in normal and hypercholesterolemic + vitamins (P<0.05 for both), but not in hypercholesterolemic pigs (P=0.1). In normocholesterolemic + vitamins pigs, Ach infusion did not induce any further increase in RBF, but RBF was similar to that observed in normal and hypercholesterolemic + vitamins under the same conditions, and tended to be higher than in hypercholesterolemic pigs (P=0.06). Thus, antioxidants improve RBF in hypercholesterolemic pigs and this effect may help to prevent renal diseases and hypertension in animals.

Item Type:Article
ID Code:3993
Status:Published
Refereed:Yes
Uncontrolled Keywords:Antioxidants, renal blood flow (RBF), hypercholesterolemia
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/07 Farmacologia e tossicologia veterinaria
Divisions:001 Università di Sassari > 01 Dipartimenti > Biologia animale
Publisher:Blackwell Publishing
eISSN:1365-2885
Deposited On:10 Jun 2010 18:04

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