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Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia

Zoledziewska, Magdalena and Costa, Gianna and Pitzalis, Maristella and Cocco, Eleonora and Melis, Maria Cristina and Moi, Loredana and Zavattari, Patrizia and Murru, Raffaele and Lampis, Rosanna and Morelli, Laura Cornelia Clotilde and Poddie, Fausto Pier'Angelo and Frongia, Patrizia and Pusceddu, Pierpaolo and Bajorek, Michele and Marras, A. and Satta, Maria Anna and Chessa, A. and Pugliatti, Maura and Sotgiu, Stefano and Whalen, Michael B. and Rosati, Giulio and Cucca, Francesco and Marrosu, Maria Giovanna (2009) Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia. Genes and Immunity, Vol. 10 (1), p. 15-17. eISSN 1476-5470. Article.

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DOI: 10.1038/gene.2008.84

Abstract

Variation within intron 19 of the CLEC16A (KIAA0350) gene region was recently found to be unequivocally associated with type 1 diabetes (T1D) in genome-wide association (GWA) studies in Northern European populations. A variant in intron 22 that is nearly independent of the intron 19 variant showed suggestive evidence of association with multiple sclerosis (MS). Here, we genotyped the rs725613 polymorphism, representative of the earlier reported associations with T1D within CLEC16A, in 1037 T1D cases, 1498 MS cases and 1706 matched controls, all from the founder, autoimmunity-prone Sardinian population. In these Sardinian samples, allele A of rs725613 is positively associated not only with T1D (odds ratio=1.15, P one-tail=5.1 × 10−3) but also, and with a comparable effect size, with MS (odds ratio=1.21, P one-tail 6.7 × 10−5). Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway.

Item Type:Article
ID Code:3977
Status:Published
Refereed:Yes
Uncontrolled Keywords:Type 1 diabetes, multiple sclerosis, Sardinia, autoimmunity, CLEC16A
Subjects:Area 06 - Scienze mediche > MED/03 Genetica medica
Area 05 - Scienze biologiche > BIO/18 Genetica
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > CRS4 Center for Advanced Studies, Research and Development in Sardinia, Pula > Genomica
001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Clinica neurologica
002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari > Ospedale "A. Segni", Ozieri > Centro trasfusionale
Publisher:Nature Publishing Group
eISSN:1476-5470
Deposited On:27 May 2010 11:33

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