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Linkage disequilibrium and population structure in wild and domesticated populations of Phaseolus vulgaris L.

Rossi, Monica and Bitocchi, Elena and Bellucci, Elisa and Nanni, Laura and Rau, Domenico and Attene, Giovanna and Papa, Roberto (2009) Linkage disequilibrium and population structure in wild and domesticated populations of Phaseolus vulgaris L. Evolutionary Applications, Vol. 2 (4), p. 504-522. eISSN 1752-4571. Article.

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DOI: 10.1111/j.1752-4571.2009.00082.x

Abstract

Together with the knowledge of the population structure, a critical aspect for the planning of association and/or population genomics studies is the level of linkage disequilibrium (LD) that characterizes the species and the population used for such an analysis. We have analyzed the population structure and LD in wild and domesticated populations of Phaseolus vulgaris L. using amplified fragment length polymorphism markers, most of which were genetically mapped in two recombinant inbred populations. Our results reflect the previous knowledge of the occurrence of two major wild gene pools of P. vulgaris, from which two independent domestication events originated, one in the Andes and one in Mesoamerica. The high level of LD in the whole sample was mostly due to the gene pool structure, with a much higher LD in domesticated compared to wild populations. In relation to association studies, our results also suggest that whole-genome-scan approaches are feasible in the common bean. Interestingly, an excess of inter-chromosomal LD was found in the domesticated populations, which suggests an important role for epistatic selection during domestication. Moreover, our results indicate the occurrence of a strong bottleneck in the Andean wild population before domestication, suggesting a Mesoamerican origin of P. vulgaris. Finally, our data support the occurrence of a single domestication event in Mesoamerica, and the same scenario in the Andes.

Item Type:Article
ID Code:3954
Status:Published
Refereed:Yes
Uncontrolled Keywords:AFL, common bean, crop evolution, domestication, epistatic selection, leguminosae
Subjects:Area 07 - Scienze agrarie e veterinarie > AGR/07 Genetica agraria
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze agronomiche e genetica vegetale agraria
Publisher:Blackwell / Wiley
eISSN:1752-4571
Copyright Holders:© 2009 The Authors, Journal compilation © 2009 Blackwell Publishing
Deposited On:27 May 2010 09:34

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