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Trichomonas vaginalis surface proteins: a view from the genome

Hirt, Robert P. and Noel, Christophe J. and Sicheritz Pontén, Thomas and Tachezy, Jan and Fiori, Pier Luigi (2007) Trichomonas vaginalissurface proteins: a view from the genome. Trends in Parasitology, Vol. 23 (11), p. 540-547. ISSN 1471-4922. Article.

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DOI: 10.1016/j.pt.2007.08.020

Abstract

Surface proteins of mucosal microbial pathogens play multiple and essential roles in initiating and sustaining the colonization of the heavily defended mucosa. The protist Trichomonas vaginalis is one of the most common human sexually transmitted pathogens that colonize the urogenital mucosa. However, little is known about its surface proteins. The recently completed draft genome sequence of T. vaginalis provides an invaluable resource to guide molecular and cellular characterization of surface proteins and to investigate their role in pathogenicity. Here, we review the existing data on T. vaginalis surface proteins and summarize some of the main findings from the recent in silico characterization of its candidate surface proteins.

Item Type:Article
ID Code:3935
Status:Published
Refereed:Yes
Uncontrolled Keywords:Trichomonas vaginalis, surface proteins, mucosal pathogens
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Elsevier
ISSN:1471-4922
Deposited On:25 May 2010 08:54

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