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Regulation of bradykinin B2-receptor expression by oestrogen

Madeddu, Paolo Roberto and Emanueli, Costanza and Varoni, Maria Vittoria and Demontis, Maria Piera and Anania, Vittorio Domenico and Glorioso, Nicola and Chao, Julie (1997) Regulation of bradykinin B2-receptor expression by oestrogen. British Journal of Pharmacology, Vol. 121 (8), p. 1763-1769. eISSN 1476-5381. Article.

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DOI: 10.1038/sj.bjp.0701255

Abstract

(1) Tissue kallikrein is overexpressed in the kidney of female rats, this sexual dimorphism being associated with a greater effect of early blockade of bradykinin B2-receptors on female blood pressure phenotype. We evaluated the effect of ovariectomy and oestradiol benzoate (50 μg kg-1 every two days for two weeks) on the vasodepressor response to intra-arterial injection of bradykinin (150–900 ng kg-1) and on the expression of bradykinin B2-receptors.

(2) Ovariectomy reduced the magnitude of the vasodepressor response to bradykinin and unmasked a secondary vasopressor effect. Oestrogen replacement restored the vasodepressor response to bradykinin in ovariectomized rats.

(3) The vasodepressor responses to sodium nitroprusside (3–18 μg kg-1), acetylcholine (30–600 ng kg-1), desArg9-bradykinin (150–900 ng kg-1) or prostaglandin E2 (30–600 ng kg-1) were significantly reduced by ovariectomy. Oestrogen restored to normal the responses to desArg9-bradykinin, acetylcholine and prostaglandin E2, but not that to sodium nitroprusside.

(4) B2-receptor mRNA levels were decreased by ovariectomy in the aorta and kidney and they were restored to normal levels by oestrogen. Neither ovariectomy nor oestradiol affected receptor expression in the heart and uterus.

(5) These results indicate that oestrogen regulates B2-receptor gene expression and function. Since kinins exert a cardiovascular protective action, reduction in their vasodilator activity after menopause might contribute to the increased risk of pathological cardiovascular events. Conversely, the cardioprotective effects of oestrogen replacement might be, at least in part, mediated by activation of the kallikrein-kinin system.

Item Type:Article
ID Code:3917
Status:Published
Refereed:Yes
Uncontrolled Keywords:Bradykinin, bradykinin B2 receptors, blood pressure, ovariectomy, oestrogen, mRNA, vasodilatation
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/07 Farmacologia e tossicologia veterinaria
Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
001 Università di Sassari > 01 Dipartimenti > Biologia animale
002 Altri enti e centri di ricerca del Nord Sardegna > National laboratory of the national institute of biostructures and biosystems, Osilo
Publisher:Stockton Press
eISSN:1476-5381
Deposited On:21 May 2010 11:14

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