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Correlation between liver histopathology and hepatitis B viral (HBV) antigen expression in hepatocytes in chronic HBV infection in relation to the phase of viral infection

Zacharia, Sabu (2010) Correlation between liver histopathology and hepatitis B viral (HBV) antigen expression in hepatocytes in chronic HBV infection in relation to the phase of viral infection. Doctoral Thesis.

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Abstract

The correlation between liver histopathology and HBV antigen expression in hepatocytes of patients with chronic HBV infection was explored in this study. Patients with documented chronic HBV infection at six months apart who satisfied the inclusion criteria underwent liver biopsy. The pathologist was blinded to the clinical and serological profile of the patients. Liver histology was assessed by HAI, and immunohistochemistry for HBcAg and HBsAg were done to asses the nuclear and cytoplasmic expression of antigens and its distribution in the hepatocytes. There was strong correlation between the presence of nuclear HBcAg, low disease activity Index by HAI and positive HBeAg and high HBV DNA in the serum. Similarly cytoplasmic HBcAg was strongly correlated with significant liver disease as per HAI and negative HBeAg status. Membranous expression of HBsAg was associated with inflammatory activity. Diffuse expression of HBsAg in the cytoplasm was inversely related with disease activity. Patients in the immunotolerant phase, had predominantly nuclear expression of HBcAg with low HAI, whereas patients in the immune clearance phase had predominantly cytoplasmic expression of HBcAg with higher HAI.

Item Type:Doctoral Thesis
ID Code:3911
Contributors:Taliani, Gloria
Publisher:Universita' degli studi di Sassari
Uncontrolled Keywords:HBV (Hepatitis virus), HBcAg (Hepatitis B core antigen), HBsAg (Hepatitis B surface antigen), HAI (Histological Activity Index)
Subjects:Area 06 - Scienze mediche > MED/17 Malattie infettive
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Cicli, scuole e corsi:Ciclo 22 > Scuole > Scienze biomediche > Patologie infettive del viaggiatore internazionale
Deposited On:19 May 2010 13:19

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