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Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin-3-ones for evaluation of antimicrobial and anticancer activity

Sanna, Paolo Antonio and Carta, Antonio and Loriga, Mario and Zanetti, Stefania Anna Lucia and Sechi, Leonardo Antonio (1998) Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin-3-ones for evaluation of antimicrobial and anticancer activity. Il Farmaco, Vol. 53 (7), p. 455-461. ISSN 0014-827X. Article.

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DOI: 10.1016/S0014-827X(98)00044-5

Abstract

A series of variously substituted quinoxalin-3-ones bearing an ethoxycarbonyl or carboxy group in the C-2 position has been prepared and their structures proved by 1H NMR spectroscopy. The obtained compounds were investigated in vitro for antimicrobial and anticancer activities. Preliminary results showed a moderate activity against a few strains of bacteria but no significant anticancer and anti-HIV activity.

Item Type:Article
ID Code:3909
Status:Published
Refereed:Yes
Uncontrolled Keywords:Quinoxalinones, antimicrobial activity, anticancer activity
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Elsevier
ISSN:0014-827X
Copyright Holders:© 1998 Published by Éditions scientifiques et médicales Elsevier
Deposited On:19 May 2010 12:18

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