Sanna, Paolo Antonio and Carta, Antonio and Loriga, Mario and Zanetti, Stefania Anna Lucia and Sechi, Leonardo Antonio (1999) Preparation and biological evaluation of 6/7-trifluoromethyl(nitro)-, 6,7-difluoro-3-alkyl (aryl)-substituted-quinoxalin-2-ones: Part 3. Il Farmaco, Vol. 54 (3), p. 169-177. ISSN 0014-827X. Article.
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A new series of quinoxalinones 6/7-trifluoromethyl or nitro- and 6,7-difluoro substituted bearing various side-chains (alkyl, halogenoalkyl, benzyl and phenyl groups) at C-3 of the ring system was synthesized and submitted to preliminary in vitro evaluation for antibacterial, antifungal, antimycobacterial, anticancer and anti-HIV activities. Results of these screenings showed that compounds 23–28 exhibited a good inhibition activity against various strains of Candida. Compound 24 showed also an interesting in vitro anticancer activity.
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