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Preparation and biological evaluation of 6/7-trifluoromethyl(nitro)-, 6,7-difluoro-3-alkyl (aryl)-substituted-quinoxalin-2-ones: Part 3

Sanna, Paolo Antonio and Carta, Antonio and Loriga, Mario and Zanetti, Stefania Anna Lucia and Sechi, Leonardo Antonio (1999) Preparation and biological evaluation of 6/7-trifluoromethyl(nitro)-, 6,7-difluoro-3-alkyl (aryl)-substituted-quinoxalin-2-ones: Part 3. Il Farmaco, Vol. 54 (3), p. 169-177. ISSN 0014-827X. Article.

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DOI: 10.1016/S0014-827X(99)00011-7


A new series of quinoxalinones 6/7-trifluoromethyl or nitro- and 6,7-difluoro substituted bearing various side-chains (alkyl, halogenoalkyl, benzyl and phenyl groups) at C-3 of the ring system was synthesized and submitted to preliminary in vitro evaluation for antibacterial, antifungal, antimycobacterial, anticancer and anti-HIV activities. Results of these screenings showed that compounds 23–28 exhibited a good inhibition activity against various strains of Candida. Compound 24 showed also an interesting in vitro anticancer activity.

Item Type:Article
ID Code:3905
Uncontrolled Keywords:2-Quinoxalinones, antibacterial, antifungal, antimycobacterial activities, anticancer activities
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Copyright Holders:© 1999 Elsevier Science
Additional Information:Part of this work was presented as a poster communication at the 13. Convegno Nazionale della Divisione di Chimica Farmaceutica, Paestum, Italy, 23–27 September 1996.
Deposited On:19 May 2010 10:27

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