Quinoxalin-2-ones: Part 5: Synthesis and antimicrobial evaluation of 3-alkyl-, 3-halomethyl- and 3-carboxyethylquinoxaline-2-ones variously substituted on the benzo-moiety

Carta, Antonio and Loriga, Mario and Zanetti, Stefania Anna Lucia and Sechi, Leonardo Antonio (2003) Quinoxalin-2-ones: Part 5: Synthesis and antimicrobial evaluation of 3-alkyl-, 3-halomethyl- and 3-carboxyethylquinoxaline-2-ones variously substituted on the benzo-moiety. Il Farmaco, Vol. 58 (12), p. 1251-1255. ISSN 0014-827X. Article.

Full text not available from this repository.

DOI: 10.1016/S0014-827X(03)00198-8

Abstract

A new series of 3-alkyl-, 3-trifluoromethyl-, 3-carboxyethyl- and 3-bromomethylquinoxaline-2-ones and 2,3-bis(bromomethyl)quinoxalines bearing Cl, CF₃, morpholine on the benzo-moiety, were synthesised and submitted to a preliminary in vitro evaluation for antibacterial and anticandida activities. Results of the screening showed that compounds 9b, 14b and 19b (MIC=62.5 μg/ml) and 10b (MIC=15.6 μg/ml) were the most active against Vibrio alginolyticus.

Item Type:	Article
ID Code:	3879
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	2-Quinoxalinones, quinoxalines, antimicrobial activity
Subjects:	Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Scienze biomediche 001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:	Società chimica italiana
ISSN:	0014-827X
Deposited On:	17 May 2010 15:54

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page