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Quinoxalin-2-ones: Part 5: Synthesis and antimicrobial evaluation of 3-alkyl-, 3-halomethyl- and 3-carboxyethylquinoxaline-2-ones variously substituted on the benzo-moiety

Carta, Antonio and Loriga, Mario and Zanetti, Stefania Anna Lucia and Sechi, Leonardo Antonio (2003) Quinoxalin-2-ones: Part 5: Synthesis and antimicrobial evaluation of 3-alkyl-, 3-halomethyl- and 3-carboxyethylquinoxaline-2-ones variously substituted on the benzo-moiety. Il Farmaco, Vol. 58 (12), p. 1251-1255. ISSN 0014-827X. Article.

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DOI: 10.1016/S0014-827X(03)00198-8

Abstract

A new series of 3-alkyl-, 3-trifluoromethyl-, 3-carboxyethyl- and 3-bromomethylquinoxaline-2-ones and 2,3-bis(bromomethyl)quinoxalines bearing Cl, CF3, morpholine on the benzo-moiety, were synthesised and submitted to a preliminary in vitro evaluation for antibacterial and anticandida activities. Results of the screening showed that compounds 9b, 14b and 19b (MIC=62.5 μg/ml) and 10b (MIC=15.6 μg/ml) were the most active against Vibrio alginolyticus.

Item Type:Article
ID Code:3879
Status:Published
Refereed:Yes
Uncontrolled Keywords:2-Quinoxalinones, quinoxalines, antimicrobial activity
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Società chimica italiana
ISSN:0014-827X
Deposited On:17 May 2010 15:54

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