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AmpliBASE MTTM: a Mycobacterium tuberculosis diversity knowledgebase

Majeed, Ahmed A. and Ahmed, Niyaz and Rao, K. Rajender and Ghousunnissa, Sheikh and Kauser, Farhana and Bose, Buddhaditta and Nagarajaram, Hampapathalu A. and Katoch, Vishwa Mohan and Cousins, Debby V. and Sechi, Leonardo Antonio and Gilman, Robert H. and Hasnain, Seyed E. (2004) AmpliBASEMTTM: a Mycobacterium tuberculosis diversity knowledgebase. Bioinformatics, Vol. 20 (6), p. 989-992. eISSN 1460-2059. Article.

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DOI: 10.1093/bioinformatics/bth051

Abstract

AmpliBASE MTTM is an online databank of high-resolution DNA fingerprints representing fluorescent amplified fragment length polymorphism (FAFLP) profiles or amplitypes developed for the Mycobacterium tuberculosis complex strains from 48 different countries. AmpliBASE MTTM is based on a relational database management system that is hyperlinked to visualize genotyping results in the form of DNA fingerprint images for individual strains. A flexible search system based on systematic comparisons of fragment sizes in base pairs allows inter-laboratory comparison of FAFLP profiles. Besides this, the database also displays previously published data on IS6110 profiles, spoligotypes, MIRU-VNTRs and large sequence polymorphisms along with the FAFLP records that will give the overall comparisons. Being the first of its kind, AmpliBASE MTTM is expected to be a very helpful tool in strengthening the concept of ‘geographic genomics’ and will be very helpful to molecular epidemiologists and those interested in diagnostic development for tuberculosis.

Item Type:Article
ID Code:3877
Status:Published
Refereed:Yes
Uncontrolled Keywords:AmpliBASE MTTM, Mycobacterium tuberculosis, DNA fingerprints databank
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Oxford University Press
eISSN:1460-2059
Deposited On:14 May 2010 19:12

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