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In vitro activity of new quinoxalin 1,4-dioxide derivatives against strains of Mycobacterium tuberculosis and other mycobacteria

Zanetti, Stefania Anna Lucia and Sechi, Leonardo Antonio and Molicotti, Paola and Cannas, Sara and Carta, Antonio and Bua, Alessandra and Deriu, Antonella and Paglietti, Giuseppe (2005) In vitro activity of new quinoxalin 1,4-dioxide derivatives against strains of Mycobacterium tuberculosis and other mycobacteria. International Journal of Antimicrobial Agents, Vol. 25 (2), p. 179-181. ISSN 0924-8579. Article.

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DOI: 10.1016/j.ijantimicag.2004.11.003

Abstract

This study describes the antimycobacterial activity of new quinoxaline derivatives against clinical isolates of Mycobacterium tuberculosis and other mycobacteria (M. bovis, M. cheloneae, M. avium sub. paratuberculosis). Isolates were collected in the Department of Biomedical Science (Sassari University). One of the most important steps of tuberculosis pathogenesis is the infection of alveolar macrophages and so for this reason, we observed the intracellular action of these drugs in mouse macrophages.

Item Type:Article
ID Code:3876
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycobacterium tuberculosis, tuberculosis pathogenesis, quinoxaline derivatives
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Elsevier
ISSN:0924-8579
Copyright Holders:© 2004 Elsevier B.V. and the International Society of Chemotherapy
Deposited On:14 May 2010 18:27

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