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Detection of virulence factors in a corneal isolate of Klebsiella pneumoniae

Pinna, Antonio <1963- > and Sechi, Leonardo Antonio and Zanetti, Stefania Anna Lucia and Carta, Francesco (2005) Detection of virulence factors in a corneal isolate of Klebsiella pneumoniae. Ophthalmology, Vol. 112 (5), p. 883-887. ISSN 0161-6420. Article.

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DOI: 10.1016/j.ophtha.2004.12.024


Objective. To report on the microbiological findings of a Klebsiella pneumoniae strain isolated from a patient with keratitis.
Design. Interventional case report.
Intervention and Testing. Conjunctival swabs and corneal scrapings from the right eye were inoculated for culture. The isolate was analyzed for the presence of the mucoid phenotype and the ability to form biofilm. We also investigated whether the formation of biofilm by the corneal Klebsiella isolate is affected by N-acetylcysteine.
Main Outcome Measures. Culture results and biofilm production were analyzed.
Results. K. pneumoniae was grown from the conjunctiva and cornea. The isolate showed the mucoid phenotype and strong biofilm production. N-acetylcysteine had an inhibitory effect on both biofilm formation and preformed biofilm.
Conclusions. K. pneumoniae can cause severe keratitis. The presence of virulence factors, such as the mucoid phenotype and the ability to form biofilm, may be important in determining corneal infection. N-acetylcysteine is a potential candidate for use as an inhibitor of Klebsiella biofilm formation.

Item Type:Article
ID Code:3875
Uncontrolled Keywords:Klebsiella pneumoniae, keratitis, virulence factors, N-acetylcysteine
Subjects:Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
Copyright Holders:© 2005 American Academy of Ophthalmology
Deposited On:14 May 2010 16:13

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