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Phages specific for mycobacterial lipoarabinomannan help serodiagnosis of tuberculosis

Bua, Alessandra and Rosu, Valentina and Molicotti, Paola and Das Gupta, Sujoy K. and Ahmed, Niyaz and Zanetti, Stefania Anna Lucia and Sechi, Leonardo Antonio (2009) Phages specific for mycobacterial lipoarabinomannan help serodiagnosis of tuberculosis. New Microbiologica, Vol. 32 (3), p. 293-296. ISSN 1121-7138. Article.

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Abstract

This study evaluated the possibility to use six phages specific to the Mycobacterium tuberculosis lipoarabinomannan (LAM) as tools for tubercular serodiagnosis. We analysed sera samples from 30 subjects with active tuberculosis (TB+), 30 with latent tubercular infection (LTBI) and 60 healthy subjects as controls (K). Our data indicated a good antibody response of the TB+ and LTBI patients against the phage Ri(7)17; the optical density (OD) values obtained from sera patients was statistically significant when compared to the control samples. Our results confirm that phage display technology might be useful to develop new tools for diagnosis of tuberculosis.

Item Type:Article
ID Code:3844
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycobacterium tuberculosis, tubercular serodiagnosis, LTBI (latent TB infection)
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Edizioni internazionali
ISSN:1121-7138
Deposited On:07 May 2010 16:57

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