De Nigris, Filomena and Tammam, Youssef and Ciafré, Silvia Anna and Franconi, Flavia and Anania, Vittorio Domenico and Condorelli, Gianluigi and Palinski, Wulf and Napoli, Claudio (2000) Evidence for oxidative activation of c-Myc–dependent nuclear signaling in human coronary smooth muscle cells and in early lesions of Watanabe heritable hyperlipidemic rabbits: protective effects of vitamin E. Circulation, Vol. 102 (17), p. 2111-2117. eISSN 1524-4539. Article.
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Background. Oxidized LDL (oxLDL) promotes atherogenesis, and antioxidants reduce lesions in experimental models. OxLDL-mediated effects on c-Myc are poorly characterized, and those on c-Myc nuclear pathways are completely unknown. c-Myc stimulates smooth muscle cell (SMC) proliferation and could be involved in atherosclerosis. We investigated the early effects of oxLDL and α-tocopherol on c-Myc, its binding partner Max, and the carboxy-terminal domain–binding factors activator protein-2 and elongation 2 factor in human coronary SMCs. We also investigated whether 9-week treatment of Watanabe heritable hyperlipidemic (WHHL) rabbits with diet-enriched α-tocopherol reduces c-Myc expression and oxLDL in the left coronary artery.
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